Why IVF implantation fails?

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Even though IVF Cyprus is the most sophisticated reproductive technology out there, it sometimes doesn’t produce the desired outcome. A common reason for that is implantation failure.

Struggling with infertility requires a strong mental preparation for coping with both expected and unexpected obstacles and failures.

Many women and couples choose to start or grow their families via in vitro fertilization (IVF). It is the most successful assisted reproductive technology that has brought the joy of parenthood to many women and couples alike.

Here you’ll learn everything on why this might happen and what you can do to improve your chances of conceiving a healthy baby.

Chin up and keep your optimism with us!

First, let’s see what’s embryo implantation

Implantation is the step of pregnancy where the embryo attaches to the uterine wall. This process enables the embryo to be supplied with nutrition and oxygen from the mother. When the embryo reaches this advanced stage of development, it is often referred to as a “blastocyst”.

Successful and complete embryo implantation is a process that relies upon continuous embryonic development and the two-way interaction between the blastocyst and endometrium (uterine lining). From a medical point of view, implantation is confirmed when the large cavity of fluid surrounding the embryo is detected on an ultrasound scan.

Implantation in IVF Cyprus treatment

In IVF Cyprus cycles, implantation is the last step of the process which may or may not lead to a successful pregnancy.

Despite the medical team’s effort to transfer 100 percent of healthy embryos, the procedure can sometimes fail. This means that there are other factors involved in the process of implantation, and by discovering them you can greatly improve your chances of pregnancy.

The role of the mother in failed implantation

Most of the factors causing infertility are related to abnormalities of the female reproductive system. Common maternal factors can include:

Non – receptive uterus

As the place where the magic of pregnancy happens, the woman’s uterus is a deciding factor whether pregnancy will or will not happen. Certain uterine issues can contribute to the failure of implantation. These can be mainly distinguished into two main groups:

Anatomical issues

Structural abnormalities of the uterus are a common cause for failed IVF cycles and these include:

  • Blocked or fluid-filled fallopian tubes
  • Presence of Fibroids
  • Uterine anomaly
  • Endometrial polyps

The good news is that these factors can be easily detected and treated prior to treatment.

Endometrial Problems

The problems that can be found in this group refers to the issues concerning the lining of the uterus. As being the main factor that determines the receptiveness of the uterus, the lining allows the embryo to attach just for a brief time (also known as a “window of implantation”). If the uterine lining was not ready, implantation is not successful.

Causes of poorly receptive endometrium are:

  • Endometrial thickness of less than 6mm
  • Thrombophilia (interrupted blood flow to the placenta)
  • Endometritis (Inflammation of the uterine lining)
  • Endometriosis (Gynecological condition of misplaced growth of endometrial tissue)

In some cases, the endometrium can cause implantation failure even without any detected abnormality. This often happens due to the interrupted interaction between the endometrium and the embryo.

Poor ovarian response

There are cases when a woman’s ovaries don’t respond adequately to fertility medications (ovarian stimulation). The result is a failure to produce multiple eggs for fertilization.

This is common for women of advanced reproductive age, as well as women with increased follicle-stimulating hormone (FSH) levels. In both situations, insufficient production of eggs can result. Having fewer eggs decreases the chances of producing good-quality embryos. This, in turn, decreases the chances of successful IVF.

Problems related to the embryo quality

The reasons behind a “weak” embryo are numerous. The biggest problem, however, is chromosomal abnormalities. Multiple studies have shown that these happen most of the time due to age. As women and men age, egg and sperm quality decreases, leading to a greater risk of chromosomal abnormalities.

Zona pellucida

Zona pellucida is the covering membrane of an embryo. Sometimes, due to the thickening of this membrane, the embryo is not able to break out from the membrane, making it impossible to proceed to successful implantation.  This step is crucial for successful implantation and any defects of the zona pellucida can negatively affect implantation.

Paternal factors

The male partner contributes to the other half of the genetic material of the embryo. Any sperm irregularities such as abnormal morphology or motility can negatively affect the genetic and morphological state of the embryo and potentially lead to implantation issues.

Lifestyle factors affecting implantation

Lifestyle significantly affects the reproductive and overall health of both partners. Bad lifestyle habits can decrease your chances of conceiving or carrying a baby to term.

Here are a few examples of bad habits that can decrease fertility rates:

  • Smoking
  • Body mass index in the obese range
  • Immoderate caffeine or alcohol intake
  • High levels of stress
  • Insufficient sleep

Common implantation failure tests

Although you may feel like there’s little to be done regarding implantation, there are a variety of tests that can improve the prognosis of successful IVF. Before starting a fertility treatment in Cyprus, it’s important to talk to your fertility doctor about tests that can provide insights into the causes of implantation failure.

Hormone blood tests

These are simple fertility tests that measure the levels of reproductive hormones in your blood. Hormone tests can be done either in your home country or at our clinic upon arrival in North Cyprus guided by the best fertility doctors in Cyprus.

Follicle-stimulating hormone (FSH) test

This test is used for the assessment of the levels of follicle-stimulating hormone (FSH). FSH is essential for egg production, and checking its levels will help you discover problems with your egg reserve or ovaries.

Thyroid-stimulating hormone (TSH) test

It’s used for the evaluation of the thyroid-stimulating hormone (TSH). Abnormal concentration of this hormone can cause conception or implantation problems.

Prolactin

The level of prolactin indicates the ability of the uterus’s lining to produce estrogen. Increased levels of prolactin can compromise the quality of the resulting embryo(s).

Anti Müllerian Hormone (AMH)

AMH is one of the hormones indicating the ovarian reserves (number of eggs in the ovaries) of the mother. It is secreted by developing egg sacs (follicles). A high AMH level indicates a good egg reserve.

Estradiol (E2)

Estradiol is a hormone secreted by the ovarian follicles. The levels of estradiol are also used to determine the ovarian reserve. High hormone levels indicate you may have a problem with your ovarian reserve, and defects with the ovaries (PCOS, tumors)

Transvaginal ultrasound scan

This test is used for monitoring the number of follicles in the ovaries (also known as antral follicle count [AFC]) and for any uterus anomalies (e.g. ovarian cysts, fibroids, polyps)

Preimplantation genetic screening (PGS) in Cyprus

This specialized genetic test is used to evaluate the quality of the embryo by scanning it for the presence of chromosomal abnormalities.

Endometrial Receptivity Assay

One-quarter of women undergoing IVF treatments fail to conceive due to unreceptive endometrium. This test is used to detect the implantation window with high accuracy in patients with experienced IVF failures.

Treatment for implantation failure

Treating implantation issues is based on the identified cause of unsuccessful implantation. Treatment should be based on the partner’s sex and furthermore, on the specific factor that’s causing implantation failure.

Treating female factors

Implantation failure may be caused by factors associated with the female reproductive system, including:

Anatomic factors

Possible treatments for anatomical problems (such as fibroids, endometrial polyps, birth defects, uterine malformations) include surgical procedures such as:

  • Septectomy
  • Myomectomy
  • Polypectomy
  • Adhesiolysis
  • Excision of sactosalpinx

Endometrial factors

These are factors related to endometrial receptivity and thickness. Common treatments include:

  • Medication (such as aspirin, sildenafil)
  • Application of mechanical stimulation
  • Estrogen therapy

There’s a group of factors that are related to the disrupted blood flow to the endometrium. Possible treatments are:

  • Low molecular weight heparin (LMWH)
  • Medication (e.g. aspirin)
  • Corticosteroids

Immunological problems

Treatment for problems with the immune system that rejects the embryo and prevents conception include:

  • High dose of intravenous immunoglobulin treatment
  • Intralipid

Treating male factor

The quality of the male’s reproductive material can also affect the quality of the embryo. The age of the eggs significantly can decrease the chances of a healthy pregnancy. The DNA quality of the sperm is crucial for the health of the embryo. The common treatment method is intracytoplasmic morphologically selected sperm injection (IMSI).

Treating embryonic factors contributing to implantation failure

These factors refer to all the issues that can decrease the quality of the embryo, and reduce the chances of attaching to the uterine wall. The treatments that would be mentioned below are helping in overcoming the embryonic contribution to implantation failure.

Genetic factors

PGD Cyprus (Preimplantation genetic diagnosis) can help avoid the danger of transferring genetic mutations of one or both parents. These genetic mutations can significantly decrease the ability of the embryo to attach to the uterine wall. PGD Cyprus detects over 100 mutations and offers to couples the possibility of successful conception.

Treating problems with embryo development

These techniques are used to deal with problems regarding the quality or development of the embryo:

  • Blastocyst culture examination
  • Assisted hatching
  • Sequential transfer
  • Zygote intrafallopian transfer (ZIFT)
  • Co-culture system

How can IVF in Cyprus prevent failed implantation?

In vitro fertilization (IVF) Cyprus is a common fertility treatment in which fertilization takes place outside the woman’s body. For conception purposes, that egg used is either from the future mother or an egg donor, which are fertilized with the partner’s or donor’s sperm in a lab.

There is a wide spectrum of IVF treatments that euroCARE offers to help you. All of them are dealing with the cause of infertility. Depending on your case, our doctor will recommend the most suited treatment plan for you (and your partner).

Blastocyst transfer

Blastocyst transfer refers to the embryo transfer that’s performed on day 5 of embryo development and is in the range of euroCARE’s IVF offered IVF treatments. Embryos that are being grown for 5-6 days in the IVF laboratory environment are able to successfully reach the phase of blastocysts. At that stage of development, blastocysts can rely on their own genetic material to produce energy. This makes them self-reliant and allows them to implant into the wall more successfully.

Assisted hatching

Assisted hatching is an advanced assisted reproductive technique that helps the embryo to break out from its outer layer (zona pellucida). Sometimes, this membrane is thick due to various factors (e.g. age, freezing). The procedure provides assurance in the hatching process of the embryo. You can also find this on the list of IVF treatments that euroCARE offers for you.

Embryo glue

Embryo glue is another approach to increase the chance of implantation post-transfer. The embryo glue is a medium containing all the nutrients needed for the embryo to grow. euroCARE makes this possible for you too.

Preimplantation genetic testing

Preimplantation genetic screening (PGS) and preimplantation genetic diagnosis (PGD) are genetic tests used to screen single cells from embryos for potential genetic defects and chromosomal abnormalities. This advanced screening technique offers couples the chance to select embryos that are genetically normal prior to embryo transfer.

PGD Cyprus can help prevent the transfer of genetic mutations, such as muscular dystrophy, sickle cell anemia, cystic fibrosis, Tay-Sachs. PGS Cyprus can help to avoid chromosomal disorders such as Down syndrome. These disorders greatly contribute to failed implantation and we are glad we can help you with this too!

Pick the best treatment option at euroCARE for a successful pregnancy!

IVF Cyprus is a great option if you’re going through difficulties to build your own family due to failed implantation. The IVF Cyprus success rates that our clinic is proudly presenting are proving that you are at the right place for making the first step towards getting pregnant!

At euroCARE, we offer many treatments that you can pursue if you have experienced failed implantation. Cutting-edge technology, quality control, and constant monitoring ensure the success of each step of conception.

Find low-cost IVF packages at euroCARE,  a modern clinic situated on the beautiful island of Cyprus. Take your first step today and book a free consultation!

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