Why IVF fails?

Last Updated on

IVF in Cyprus is one of the most successful and affordable reproductive technologies available today. Though, sometimes it doesn’t result in a positive pregnancy test. There is a wide list of factors that can affect your fertility, and the success of the IVF treatment as well. 

A failed IVF Cyprus cycle can be very overwhelming for the couple/individual who underwent the treatment. It can be devastating both mentally and financially. It is devastating for us as a medical team too. Therefore, it is very important to use the failed IVF cycle as a lesson learned and to carefully examine the reasons for the failure. That way, it is going to be possible to overcome the problem and increase the chances of success next IVF Cyprus treatment. 

Struggling with infertility and proceeding to an IVF treatment means strong mental health for coping with the expected and unexpected obstacles and potential failures. Thus, it is crucially important to be well informed, follow the fertility doctor’s instructions, keep the attitude positive and most important, see every failure as a new opportunity!

EuroCARE IVF team of experts is listing the several most common reasons for a failed IVF cycle. By that, we would like to face you with the possible negative outcome and familiarize you with the solutions and practices that may prevent it. Here you’ll learn everything on why this might happen and what you can do to improve your chances of conceiving a healthy baby. 

Chin up and keep your optimism with us! 

What are the possible causes of failed IVF?

As with many medical treatments, an IVF cycle can have several “weak spots” in some of the procedural steps. They mostly depend on the reproductive health of the patients and the individual body’s reaction to the treatment. For those weaker points that are possible to predict, the IVF technology offers special and additional enhancing tools. Within the most common reasons for IVF failure are the following: 

  1.     The age and health of the patient
  2.     The quality eggs, sperm, and embryos
  3.     The condition in which the endometrium and hormone levels are
  4.     The high-level laboratory support and their dedication to the patient
  5.     The level of experience of the medical staff


Unfortunately, the human body and its feedback on certain medications and reproductive technologies can not be 100% accurately predicted. So, some subtle reasons for failure are not familiar even to the specialists and are hardly measurable.
So, let’s take a look one by one at the most common reasons for failed IVF cycles together with possible solutions for it!

Age and its negative effect on fertility and IVF cycle

Age plays a significant role in the quality of your reproductive health. There is a certain decline in one’s fertility and in the quality of the reproductive material due to age. It occurs earlier in women than in men. Age affects both the ovarian reserves in the woman, but also the quality of the reserve. In man, it also affects the overall sperm count, but also the quality factors (motility, morphology, density).

Fertility specialists are able to evaluate a woman’s “ovarian reserve” using a variety of tests as part of the standard fertility evaluations. These tests can evaluate primarily the quantity of the eggs, but it is hard to examine the quality and predict the response of ovaries to the IVF stimulation.

The low ovarian reserve can also cause a cancelation of an IVF cycle. The standard IVF Cyprus cycle contains an ovarian stimulation phase. If some women fail to respond to the fertility medications as expected, the ovarian stimulation protocol should be revised in the next IVF cycles or an alternative IVF treatment should be decided. There is still no qualitative method for evaluating with 100% accuracy the quality of the eggs. Therefore, here the medicine offers mostly preventive solutions. 

How to prevent failure due to poor egg quality?

There are several solutions and preventive technologies to avoid this problem. 

The fertility diet is solely a preventive method. The quality of the eggs once harmed can not be improved. But, on the other side, fertility diets and certain lifestyle changes are done on time can improve your overall health. Thus, your reproductive health will prosper too.  With or without planning to get pregnant soon, women and men after 25 should be more aware of preserving their bodies fit and fertile.

Cryopreservation has been a useful tool for some women. In order to avoid the risk of aged reproductive material,. women at the pick of their fertility, who want to postpone being pregnant at that certain moment, can freeze their egg for future use in an IVF cycle.

IVF with an Egg donor is a suitable treatment option for women whose ovarian reserve has a weak response to the hormonal IVF stimulation medications. Even though the highest dosage of medication is used or different methods are tried, sometimes the result is not favorable to the IVF process. For this reason, our medical team can recommend using an Egg Donor. 

IVF with sperm donor is suitable for those where the main reason for failed IVF Cyprus cycle was an irregularity within the partner’s semen. EuroCARE offers this possibility for those who have been struggling with starting a family due to man infertility. Through suitable and careful selection of the sperm donor and his reproductive material, the IVF process can get higher chances of success.

Poor embryo quality

A flawed embryo is one of the most common issues for failed IVF cycles. Sometimes, no matter if the embryo might look good before the transfer, some subtle defects can cause complications. 

The first implication from a poor embryo quality is failed embryo development. During an IVF Cyprus cycle, the fertility team will observe and monitor the embryos from 3 to 5 days during their growth, before the final transfer. On the third day, the quality embryos should reach 6- to 8-cell stage, and have an outline for a regular shape.
The flawed embryos that won’t reach the 6 to 8 – cell stage during the few days of development cannot be used for embryo transfer. If this happens for all the embryos after the fertilization, then your IVF cycle might get canceled. 

Secondly, some embryos that do reach the proper development stage may be aneuploid (contain some chromosomal abnormality). Aneuploid embryos are hardly implanted. Usually, they lead to failed implantation. Those who manage to the implant, usually are causing miscarriages in the early stages of pregnancy. These subtle defects are often linked to chromosomal or genetic abnormalities in the reproductive material of any of the partners.

The third problem that can occur and is related to the embryo is the thickening of the zona pellucida. This membrane sometimes fails to break and release the embryo. Thus, the embryo is not able to implant properly and attach to the uterus. 

How to prevent failure due to poor embryo quality?

Assisted reproductive technologies offer tests suitable for this situation. Preimplantation genetic screening (PGS) and Preimplantation genetic diagnosis (PGD) can be done on the embryo before the transfer. These two methods can help in identifying genetic and chromosomal disorders that can negatively influence the IVF cycle and even more, the pregnancy (if happen).

Even so, these tests are not part of the standard fertility evaluation. EuroCARE IVF is providing this solution on request of the couple, or if our fertility doctors consider it a tool to improve your chances for a successful and healthy pregnancy after IVF. As they are not always done, the risk of failed IVF is bigger.  

Untreated diseases prior to the time that a couple wants to get pregnant 

Certain diseases that haven’t been treated on time, can leave a “scar” on our bodies. Some of those such as:

  • Celiac disease
  • Diabetes
  • Thyroid disorders
  • Autoimmune disease

can decrease the chances of proper embryo development, successful implantation or a healthy pregnancy. 

The listed diseases can easily affect the hormonal levels in the body and easily cause weight changes, which directly influence the reproductive system. In the worst case, autoimmune diseases can develop an immunological reaction of the body – treating the transferred embryo as a foreign body, and cause failed IVF. 

Implantation failure

Implantation is the stage of pregnancy where the embryo attaches to the uterine wall. This process enables nutrition and oxygen for the embryo. When the embryo reaches this advanced stage of development, it is often referred to as a “blastocyst”. Successful and complete embryo implantation is based on continuous embryonic development and mutual interaction between the blastocyst and endometrium (uterine lining). Behind the implantation failure, there are several types of reasons. 

Majority of them is related to non-receptive uterus caused by anatomical issues, such as

  • Blocked fallopian tubes
  • Fibroids
  • Endometrial polyps

Or linked with endometrial problems such as:

  • Endometriosis
  • Thin endometrium

Furthermore, the reasons mentioned above, such as poor quality reproductive material, or embryo can lead to a failed IVF cycle. 

How to prevent failed implantation in IVF Cyprus cycle?

The first step of resolving this risk is usually getting rid of the existing problem (if any) within the woman’s uterus. Either surgically, or with medical therapy, the above mentioned anatomical and endometrial difficulties can be resolved.

Furthermore, there are IVF complementary technological enhancements that can increase the chances of successful IVF Cyprus treatment. Within those can be found: 

  • Blastocyst transfer (Embryo transfer of embryo developed on day 5, after they are being grown in lab conditions, instead of in woman’s body)
  • Assisted hatching (ART technique that supports embryo’s hatching and successful implantation)
  • Embryo glue (ART technique that increases the chances for implantation) 

Development of conditions during the IVF cycle that causes cycle cancelation

Cancelation of the IVF cycle at a certain point during the treatment is possible. It is not happening very often, but usually, the number of eggs that are produced during the ovarian stimulation phase can determine the success. 

In some women, the treatment is canceled after the ovarian stimulation phase due to too little eggs produced and viable for fertilization.

In other women, the problem is exactly the opposite. In some women, the ovarian stimulation phase can cause Ovarian Hyperstimulation Syndrome (OHSS). This condition requires time to settle down and recover. 

Therefore, the IVF cycle is stopped at this point.

How to prevent failure due to unfavorable conditions developed?

Assisted reproductive technologies are developed to cover many infertility issues. Even more, the variety of treatments developed is meant to give chances for everyone. 

If a couple/individual has a history of canceled IVF cycles due to OHSS, or history of conditions that can cause OHSS, then its possible to be recommended with Mini IVF.  Mini IVF is a type of IVF Cyprus treatment that is done with a minimal dosage of fertility stimulation drugs, and that significantly decreases the risk of OHSS.

Of course, there are certain criteria that the patient has to fulfill to be approved for a Mini IVF Cyprus cycle. In these cases, it is recommendable to have full trust in the fertility doctor responsible for your case. 

The clinical conditions and fertility team experience 

Sometimes, this can be a factor leading to failed IVF. A successful IVF treatment requires a highly experienced team and individual approach to each patient with a high level of devotion. Some clinics fail to examine accurately the condition of the patient and that can cause later complications.  The establishment of the right ovarian stimulation protocol, the performance of the IVF procedures, the support through all the steps of IVF is a must for a successful outcome from the treatment.

Therefore, be careful when choosing the right clinic and team for your journey to motherhood!

How can euroCARE IVF help in avoiding failed IVF? 

The IVF Cyprus success rates that our clinic is proudly presenting are proving that you are at the right place for making the first step towards getting pregnant! Our team is devoted to offering customized solutions for each patient individually, no matter your circumstances.  At euroCARE, we offer many treatments and IVF cycle enhancements that you can pursue if you want to increase the chances of success.  

Find low-cost IVF packages at euroCARE,  a modern clinic situated on the beautiful island of Cyprus. Take your first step today and book a free consultation!

References:
https://www.huffpost.com/entry/opinion-merrill-ivf-failure_n_5adf8637e4b061c0bfa27b19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510376/
https://timesofindia.indiatimes.com/blogs/your-fertility-friend/having-a-failed-ivf-cycle-know-what-went-wrong-to-have-a-positive-2nd-ivf-cycle/

 

Live chat with patient coordinators

Please fill the form to start chatting with one of our patient coordinators.