What is fragmentation and how does it occur?

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As embryos divide, sometimes a small portion of cytoplasm (the inside of the cell) breaks off and forms what we call a fragment. Fragments do not contain nuclei and are not considered cells. The causes of fragmentation are poorly understood, but embryos containing a lot of fragmentation are developmentally disadvantaged simply because the cells lose too much cytoplasm and thus, cellular machinery, to the fragments.

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